While many advocates of marijuana are pleased by this changing tide, their pets are a different story. Little data is available on how non-human animals respond to marijuana, but all the evidence we do have suggests the psychoactive components of the drug are rather unpleasant for Scruffy. "The most common clinical signs after ingesting marijuana are ataxia (drunken gait), lethargy, and urinary incontinence," Wismer of the ASPCA writes. "However, about 25 [percent] of patients may present stimulated instead." For these doggos, things can get dangerous—they may experience disorientation, a slowed heart rate, low body temperature, dilated pupils and tremors. If dogs get into a stash with high concentrations of the psychoactive compound THC, Wismer says they may even experience a steep drop in blood pressure or slip into a coma.