Because the two tests look for different things, they each have their pros and cons. The DNA test could catch women who are infected with the high-risk HPV types, but whose Pap smears still appear normal. That happens to about in about 1 in 10 women with normal Pap smears, The Verge reports. On the other hand, not all HPV infections lead to cancer. Most adults actually get HPV once they become sexually active and fight off the infection successfully without even knowing it. Opponents to replacing Pap smears with cobas HPV tests worry that the DNA tests could lead to unnecessary biopsies, yowch. But the U.S. Food and Drug Administration, which approved the cobas HPV test as Pap smear alternative this week, says it has data showing this doesn't happen, The Verge reports.