The pill turned 50 this year, and it has gone through many iterations since the Food and Drug Administration gave the pharmaceutical company G.D. Searle a green light to market the first oral contraceptive on June 23, 1960. Drug companies continually roll out contraceptives containing lower doses of hormones and entailing fewer side effects. But women who have gone on hormones can point to the effects that have stubbornly endured: moodiness, depression, decreased libido. (This last one makes some birth control pills perversely effective. Not only do they protect you from pregnancy if you do have sex, they also zap your desire to have sex in the first place -- and turn you into an unstable mess, which may in turn zap your partner's interest in sex.) But believe it or not, we still know very little about the consequences of taking daily hormones on a woman's brain.