Found: A Weird New Pluripotent Cell Type

It turns out we have a lot left to learn about stem cells

photo of induced pluripotent stem cells dyed with fluorescent dyes

Induced Pluripotent Stem Cells

These cells were made from a woman's skin.Kathrin Plath lab, University of California, Los Angeles, via CIRM

Hold your horses. There's a new kind of pluripotent cell in town.

Pluripotent cells are exciting because they're able to turn into almost any kind of cell in the body. That means they're promising for treating injured organs and for other regenerative medicine. Stem cells—you've heard of those—are pluripotent. These new guys aren't quite as powerful as stem cells and may never appear in treatments. But they reveal how much more there is to learn about stem cells and how to make them useful in medicine.

For nearly a decade now, scientists have been able to transform regular cells, often taken from a skin biopsy, into induced pluripotent stem cells in lab. Induced pluripotent stem cells are the embryo-like stem cells that doctors just began testing this year as a therapy for age-related macular degeneration, a progressive disease that leads to blindness. In a new study, an international team of biologists used similar, but not exactly the same, methods to create the new kind of pluripotent cell. Team members named the new guys F-class cells because they look fuzzy when they're growing together.

The F-class cells can't make weird chimeric mice, the way induced pluripotent stem cells do. Nevertheless, they're able to turn into different tissue types. This is a state of pluripotency that scientists have never seen before.

Think of it like knowing how to bake cookies, without knowing exactly why the recipe works.

Even though they're starting to test induced pluripotent stem cells for therapies, scientists still have a lot of questions about what happens when they make those cells. Think of it like knowing how to bake cookies, without knowing exactly why the recipe works. The F-class pluripotent cells represent another step in learning more about man-made stem cells.

In fact, the team is publishing a paper about their F-class cells at the same time as three other papers that describe more about the myriad ways adult cells react to getting dosed with the proteins that turn them into induced pluripotent stem cells. After all, when people make induced pluripotent stem cells, they always make many other weird cells along the way. They may make 1,000 of these other, strange cells for every one induced pluripotent stem cell they make. Since 2011, there's been an international effort to characterize what's happening when induced pluripotent stem cell-making fails. The hope is that the more scientists know about this process, the better they will be able to control it—and perhaps create more stem-cell therapies.