As a health editor and self-proclaimed hypochondriac, I was surprised and interested (a disease I had never heard of!). Turns out, the culprit is capsaicin, a chemical compound found in the fruit of plants within the capsicum family, including red chili peppers, jalapeños, and habaneros. This colorless and odorless compound binds to pain receptors, triggering the sensation of intense heat or burning. But I won’t ruin all the surprises that come with jalapeño hands. Listen to this week’s episode for more about this bizarre reaction to hot peppers, how to treat it, some crazy case studies, and of course, some hot pepper cutting best practices to prevent the burn.