![](https://www.popsci.com/wp-content/uploads/2019/03/18/E7DCZPYALEG7DRXRBZUF4QUD5M.jpg?quality=85&w=2560)
![](https://www.popsci.com/wp-content/uploads/2019/03/18/E7DCZPYALEG7DRXRBZUF4QUD5M.jpg?quality=85&w=2560)
In Pakistan, there lives a family of five with a unique – and tragic – condition. Several of their children cannot sweat. It’s an extremely rare disorder called anhidrosis, and while it may seem like a nice trait to have, the ability to sweat is crucial for regulating body temperature. In order to remain cool, the kids spend their days in their house’s cellar, because in daylight, they’d overheat and go unconscious. Too much sun could ultimately kill them.
Now a group of scientists are decoding the mystery surrounding this bizarre disorder. By mapping the genome of each individual in the Pakistan family, researchers from Uppsala University in Sweden identified a single genetic mutation responsible for the condition. Known as ITPR2, the gene is responsible for controlling sweat production, and knocking it out can stop sweat secretion altogether.
Lead researcher Niklas Dahl stumbled upon the rare family in his quest for understanding single-gene diseases, also known as Mendelian disorders. Dahl notes that anhidrosis has been seen before, but usually in conjunction with other skin defects. This family is the first he knows of to have anhidrosis as a primary isolated defect.
“Sweat glands made us develop this capability of walking and jogging for miles and miles without stopping.”
After analyzing the genomes of the family members, Dahl and his team zeroed in on the culprit, ITPR2, which encodes a protein called IP3R2. This protein forms a calcium channel in the brain that releases calcium when opened, triggering a chain of events in the body that eventually result in sweat secretion. “In the brain, you have temperature sensitive cells, and they send signals to the nervous system, which send signals to the periphery, then to skin and to the sweat glands, and that induces sweating,” Dahl, a genetics expert at Uppsala, tells Popular Science.
For the members of the Pakistan family, their calcium channels never open. The researchers further demonstrated this defect by creating a series of genetically engineered mice without any IP3R2 production. Sure enough the rodents had reduced sweating.
Understanding the mechanisms behind sweating can actually help researchers develop drugs to reduce excessive sweating, a condition that affects two percent of the population. People with this disorder, called hyperhidrosis, start sweating in their palms, soles of their feet, chest, armpits, and other areas of the body without any provocation. Some patients will even wear plastic underneath their clothing to avoid an embarrassing situation.
Botox has proven to be somewhat effective against hyperhidrosis, but the treatments can be painful and awkward (getting injections in your armpits cannot be fun). Dahl says that lowering IP3R2 protein levels may be a much simpler solution. “We have found a way to inhibit production of this calcium channel,” Dahl says. “It is targeted and very specific at least from a design point of view. We can reduce peripheral sweating by 60 percent.”
Dahl also says their research highlights just how important our pungent skin secretions are from an evolutionary perspective. Humans have the highest capacity for sweating on Earth, in relation to our body size and lack of hair. This gives us the advantage of being able to exercise for very long periods of time — up to 10 hours a day.
“Fast animals run faster than us, but they can only run for a few minutes. For humans, we could move over enormous areas because of this ability, making us very good hunters,” says Dahl. “Sweat glands made us develop this capability of walking and jogging for miles and miles without stopping.”
So thank you, sweat, for helping to keep us at the top of the food chain.
The researchers published their work in the Journal of Clinical Investigation.