This Lung-On-A-Chip Is The First Lab-Ready Mini-Organ to Be Used in Drug Research

Breathe In Scientists create a vacuum in the green channels bordering the blue rubber strip, which forces it to stretch, contract, and simulate breathing. Kristin Johnson/Donald Ingber/Benjamin Matthews/Martin Montoya/Dongeun Huh/Akiko Mamoto/Hong Yuan Hsin

This ersatz lung, no bigger than a multivitamin, could represent a new pharmaceutical testing method. On it, researchers have created an artificial alveolus, one of the sacs in the lungs where oxygen crosses a membrane to enter the body’s blood vessels. A polymer sheet that stands in for the membrane is in the blue strip. On one side of the sheet, blood-vessel cells mimic a capillary wall; on the other, lung-cancer cells mimic lung epithelial cells.

Scientists have tested the chip’s immune response, and it behaves just like real tissue would, a first step to having lifelike organ systems on which drugs can act. The chip’s primary developer, biomedical engineer Dongeun (Dan) Huh of Harvard University, hopes that within two years, the chip will succeed in mimicking the process by which the lungs swap oxygen for carbon dioxide. Huh would like to create a suite of artificial organs to be used in cosmetics testing and pharmaceutical safety trials.