Thanks to miracle compound BBG, mice turn blue, regain ability to walk

Awwwww:  University of Rochester

The next time someone tries to argue that all M&Ms are the same, no matter the color, you can tell them about the blue M&M. The candy (like Gatorade and other products) gets its color from a food dye similar to Brilliant Blue G (BBG) -- a compound that, as it turns out, is medically useful. Building on earlier research, scientists at the University of Rochester Medical Center have found that injections of BBG can relieve mice of secondary spinal cord injuries. In September, they will start conducting human clinical trials.

BBG works by inhibiting the function of P2X7, a molecule that pervades the spinal cord and assists another molecule, adenosine triphosphate (ATP), in killing off healthy motor neurons. Because quantities of ATP flow to the spinal cord post-injury, significant secondary injuries occur, which is why thwarting ATP's activity is absolutely vital.

The U of R researchers were able to do just that, via injections of BBG. While rodents that hadn't received the dose were never able to scurry around again following their injury, the mice that received the BBG regained their ability to walk (albeit with a limp).

The mice also turned temporarily blue, as a side-effect (the only one). The verdict here at Popsci.com is that it's only a matter of time before pet stores start selling a rainbow of rats.

[Via CNN.com]

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13 Comments

well im going to get as many blue m and ms as possible.
www.youtube.com/watch?v=hEUWrj7SyPk

In the X-Men comics. Beast turns blue as a side effect of a medical procedure. Th accuracy is.. kinda spooky.

Well I'll be smurfed!

I feel a bit sad for small rats,I don't know the reason ,maybe I think they're so lovely and poor

Well... I guess it's not "the cure for the BLUES" anymore
Now the cure IS the BLUES!!!!!!!

you can help find a cure if you have a computer http://boinc.bakerlab.org/rosetta/

Look at how blue it is...

Mira - Teeth Whitening Specialist

My kin from southeast Kentucky told me about the "blue people" that lived in some of the hills and hollows, something to do with their genetics, I just took them for their word. These rats may be direct descendants.

Here is something that I looked up to calm my overly curious mind.

"Six generations after a French orphan named Martin Fugate settled on the banks of eastern Kentucky's Troublesome Creek with his redheaded American bride, his great-great-great great grandson was born in a modern hospital not far from where the creek still runs.

The boy inherited his father's lankiness and his mother's slightly nasal way of speaking.

What he got from Martin Fugate was dark blue skin. "It was almost purple," his father recalls.

Doctors were so astonished by the color of Benjamin "Benjy" Stacy's skin that they raced him by ambulance from the maternity ward in the hospital near Hazard to a medical clinic in Lexington. Two days of tests produced no explanation for skin the color of a bruised plum.

A transfusion was being prepared when Benjamin's grandmother spoke up. "Have you ever heard of the blue Fugates of Troublesome Creek?" she asked the doctors.

"My grandmother Luna on my dad's side was a blue Fugate. It was real bad in her," Alva Stacy, the boy's father, explained. "The doctors finally came to the conclusion that Benjamin's color was due to blood inherited from generations back."

Benjamin lost his blue tint within a few weeks, and now he is about as normal looking a seven-year-old boy as you could hope to find. His lips and fingernails still turn a shade of purple-blue when he gets cold or angry a quirk that so intrigued medical students after Benjamin's birth that they would crowd around the baby and try to make him cry. "Benjamin was a pretty big item in the hospital," his mother says with a grin.

Dark blue lips and fingernails are the only traces of Martin Fugate's legacy left in the boy; that, and the recessive gene that has shaded many of the Fugates and their kin blue for the past 162 years.

They're known simply as the "blue people" in the hills and hollows around Troublesome and Ball Creeks. Most lived to their 80s and 90s without serious illness associated with the skin discoloration. For some, though, there was a pain not seen in lab tests. That was the pain of being blue in a world that is mostly shades of white to black."

www.rootsweb.ancestry.com/~kyperry3/Blue_Fugates_Troublesome_Creek.html

Blue people continued:

"THE BLUE PEOPLE OF TROUBLESOME CREEK
The story of an Appalachian malady, an inquisitive doctor, and a paradoxical cure.
by Cathy Trost
©Science 82, November, 1982

I don't want to give away the story line, it is best told by the link above, but the cure for this blood disease that was found later would astound you...

Love the way the article talks about the rats' injuries being cured. These aren't rescued rats with spinal injuries. These cute little rats had their backs broken and then were injected in their spines with blue dye. Yes the rat with the blue nose and mittens is adorable, but the reality is that these animals are being tortured for a cure to spinal injuries that is not very likely to work in humans. And what is the story with the Blue people? Not the same subject as the rats.

In response to siz113 - And what is the story with the Blue people? Not the same subject as the rats.

Your right there is something agonizing about that image. It all starts with where do we draw the line rats/mice whatever you want to call them deserve some respect. Through numerous test done on rats very few end up successful in humans.

This is, as Paul Harvey would say, is "The rest of the story" about the "Blue People"

The "Blue People" was an interesting read because the treatment was methylene blue tablets that turned the "Blue Peoples" skin pink.

I don't know how much of these claims are true but it looks like the blue mice dye isn't the first blue dye that had healing powers...

" Methylene blue was identified by Paul Ehrlich about 1891 as a successful treatment for malaria. Methylene blue combined with light has been used to treat resistant plaque psoriasis, AIDS-related Kaposi's sarcoma, West Nile virus, and to inactivate staphylococcus aureus, HIV-1, Duck hepatitis B, adenovirus vectors, and hepatitis C. Phenothiazine dyes and light have been known to have virucidal properties for over 80 years. In some circumstances, the combination can cause DNA damage that may lead to cancer. Combined with Plant Auxin, it is being investigated for the treatment of cancer."

large doses of methylene blue are sometimes used as an antidote to potassium cyanide poisoning, a method first successfully tested in 1933 by Dr. Matilda Moldenhauer Brooks in San Francisco.

Methylene blue was also used at mid-century in the treatment of carbon monoxide poisoning
TauRx Therapeutics has reported that methylene blue (methylthioninium chloride), under the tradename rember, may provide a way of halting or slowing the progression of Alzheimer's dementia. However, the formulation used was different from that commonly available as a medicine and caution has been expressed about use of methylene blue as a treatment for Alzheimer's

In vitro studies suggest that methylene blue might be an effective remedy for both Alzheimer's and Parkinson's disease by enhancing key mitochondrial biochemical pathways. It can disinhibit and increase complex IV, whose inhibition correlates with Alzheimer's disease.

Methylene blue is used in aquaculture and by tropical fish hobbyists as a treatment for fungal infections. It can also be effective in treating fish infected with ich, the parasitic protozoa Ichthyophthirius multifiliis. It is usually used to protect newly laid fish eggs from being infected by fungus or bacteria. This is useful when the hobbyist wants to artificially hatch the fish eggs.

Methylene Blue is also very effective when used as part of a "medicated fish bath" for treatment of ammonia, nitrite, and cyanide poisoning as well as for topical and internal treatment of injured or sick fish as a "first response

www.en.wikipedia.org/wiki/Methylene_blue

wow thats preety cool but rlb2 just keeps saying stuff that nobody will ever read i guess thats my appion but you all have your own peace

AndromedaStorm

It makes you wonder if it will do the same to people, turn them blue...



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