The changes in individual disease risk were all fairly small. They're significant across a population, and since many thousands of people take hormone therapy, it's vital to note even slight increases. For an individual, however, it's less concrete. We can't predict exactly how much any one person's risk of, say, breast cancer will change on hormone therapy. It varies based on how soon after menopause they start, how long the therapy lasts, how high the dosage is, the method of hormone delivery—and the list goes on.