A new strain of the gonorrhea bacteria can resist all available antibiotics, doctors say. Gonorrhea is one of the world's most common sexually transmitted diseases, so this could portend a major threat to public health.
This should actually not be surprising, because for some time now, just one class of drug has been able to successfully treat the infection.
Now researchers in Sweden and Japan identified a new variant of Neisseria gonorrhoeae, the bug that causes gonorrhea, that can survive that last remaining drug, the cephalosporin-class antibiotics. Researchers isolated the strain from the throat of a sex worker in Japan, the Los Angeles Times reports.
"This is both an alarming and a predictable discovery," said Dr. Magnus Unemo, of the Swedish Reference Laboratory for Pathogenic Neisseria, in a statement. The bacteria has been evolving to resist antibiotics since they became the standard treatment for the infection in the 1940s, during World War II.
The researchers were able to pinpoint four new genetic mutations that enable the bacteria's resistance. Even worse, it readily passes on this resistance to other strains, increasing their resistance 500-fold, the Times says.
Gonorrhea is a particularly troubling and interesting bug. It is one of the only diseases that is unique to our species, and it's one of the oldest known human pathogens. Earlier this year, researchers found a fragment of human DNA in the genome of Neisseria gonorrhoeae, evidence that it has adapted to its hosts quite well. The bacterium apparently picks up a genetic sequence from the host it's infecting, according to that research, which was published in February. This may lend N. gonorrhoeae the ability to develop different strains of itself — and can explain why it has been so effective at morphing to evade antibiotics' assaults.
The first treatments against gonorrhea used sulfonamides, but the bacteria evolved to resist it; later treatments used penicillin, which also no longer works; tetracyclines and fluoroquinolines like Cipro don't either, the L.A. Times notes.
It's too early to tell whether this new super-STD is already spreading, but it's likely to do so unless new therapies are developed, Unemo said.
Gonorrhea impacts about 700,000 Americans every year, according to the Centers for Disease Control and Prevention. If untreated, it can lead to serious health complications in both genders, the CDC says. It can lead to infertility in women and especially men, and it increases the risk of transmitting other STDs, like HIV. Babies born to infected mothers are at high risk of developing serious infections and blindness. About 3 to 4 percent of the time, it can spread to the skin, blood, heart and joints in infected adults.
The report on this new strain was presented Sunday at a Quebec City meeting of the International Society for Sexually Transmitted Disease Research. Just last Thursday, the CDC reported growing numbers of gonorrhea infections that require unusually high doses of cephalosporins to cure them, the LA Times said. For now, treatment should include cephalosporins and the antibiotic azithromycin, while the CDC and National Institutes of Health work on new drugs.
This bug sounds really dangerous. This super bug, if impossible to treat, I wonder what kind of damage it does to a person in the short run, middle and long term. I do hope they develope a cure for this and HIV soon.
The porn industry will never be the same.
And this, children, is why you don't have sex with someone unless you're married to them.
@onihikage. Yeah right. Back in your hole.
This is why if you are sexually active you should use protection. If you are allergic to latex there are products made of other materials out there. Have fun and be safe.
Oh!!! Don't forget children, cheating wives are a myth as are are cheating husbands. In fact cheating is actually just wives and husbands playing a friendly game of put the cylinder in the shape, with other close friends of theirs.
Lol... actually against gonorrhea even abstinence is no good! Even just speaking with an infected person could cause you to get it(Although quite the low odds for this one), if a single drop of their saliva touches your lips and is swallowed you'd be infected,... very unlike HIV!
anyone else see need for a mass extermination of the infected in dire need here?
@gizmowiz why would this change the porn industry at all????
people in the industry get tested for deaseses constantly. they even carry around cards or other proff when they were lasted tested and by who.
People in the porn industry probably have LESS STDs than you average high school football team.
@Onihikage and yeah.... "don't have sex with someone unless you're married to them." this doesnt even make sense in the least.
Just be smart about it, use protection. I am not saying being a player is okay, but I see no reason why two consenting adults cant have pre martial sex.
there is no ethical or moral reason not to have sex before marriage. Just use your head, and dont forget peoples emotions are involved.
"Colloidal silver", on the internet and books you can find lots of positive things said about colloidal silver or silver in drinking water. Silver being used to kill bacteria has a long history; 1000 of years even. But, interesting enough, it's not a cure all for everything! Yes, it is use in medicine. If you do a YouTube search of colloidal silver, you will find a man, who made his own and was drinking the water he made from it. His process was either wrong or he drank too much and built up to much silver in his body. It causes him to turn blue. To look at this man’s face, it is really blue. I believe he says on the video, his whole body is blue and it just happen to him so gradually he did not even notice at first. Even his wife did not immediately notice too. This is a scientific fact side effect of getting to much silver in your body. I do hope they find a cure for this soon. I feel bad for the people who have this disease.
Oh Noes, Zombie Dicks!
I don't care being blue if i ain't at risk of bacterias!
Then we'd all be like:
Yo listen up here's a story
About a little guy that lives in a blue world
And all day and all night and everything he sees
Is just blue like him inside and outside
Blue is his house with a blue little window
And a blue corvette
And everything is blue for him and hisself
And everybody around
Cos he ain't got nobody to listen to
I'm blue da ba dee da ba die...
@inaka_rob: Seriously? No moral or ethical reason not to have premarital sex? Do you even know what those words mean? If people would learn a little self control diseases like this would not spread so much and we would not have to worry about them.
"The glory of God is intelligence."
I believe your right, unfortunately humans have a great nack for being stubborn and unintelligent self serving douche bags
and in that idiots case immoral ignorant pigs.
If we really want to look at it from a scientific viewpoint, and rather than intolerantly bash on people, the solutions available really are quite simple to figure out. This big has been morphing for thousands of years, evolving to better avoid being killed by us and to basically eat better and reproduce better, at our expense. That's billions of generations of adaptation. When something like penicillin came around, the bug had no chance left to survive other than to not come into contact with the penicillin. Until thousands of generations had passed and it developed a resistance, and no longer had to worry about penicillin.
WE, however, are able to design our own resistances to the bug. So we don't have to take millions of generations to develop one naturally. BUT, just like the bug, we currently have no way to deal with this current "untreatable" form of the bug. The only answer is to avoid contact with it until the day when we do develop some kind of resistance. Until that time, people who don't avoid contact will be weeded out of the genetic pool, just like any other organism. Except that since we are smart enough to avoid it, nature will be weeding out those people who aren't smart enough or controlled enough to avoid it. People can flirt with it by using protection, but in the end, protection is not 100% effective as a means to avoiding STDs.
So whether people approach this from the moral or religious side, calling it abstinence or fidelity, or if they approach it from the naturalist or scientific side, and call it an intelligent decision of self-preservation, the only way to avoid getting beat by this bug is still to avoid coming into contact with it.
ok fine 10 points for the guy who didn't rant
These drugs they mention like 'Cipro' / ciprofloxacin works by binding up and removing iron from the invader in this case gonorrhea. When the body has too much iron the body cannot rid itself of the invader because the invader NEEDS iron to survive . THAT is why iron binding drugs are used.
"Ciprofloxacin: a novel therapeutic agent for iron overload?"
The government has only recently begun to add EVEN MORE iron to our food because they say we are all dying from lack of iron. This has been shown to be bad for people who have to avoid iron like people taking antibiotics.
"Iron inhibits the absorption of antibiotics (when taken together). You should wait a few hours before or after taking an iron supplement"
The government in their sheer stupidity is causing rampant antibiotic resistant disease by adding iron to our foods.
"Availability of iron for bacterial multiplication plays a critical role in infection."
@marcoreid, Well put. I was about to say something to that effect, but you beat me to it and probably said it better.
@calebscape808, I don't think you have any idea what a real rant is.
Quote: Neisseria gonorrhoeae
Answer: "For growth and proliferation, N. gonorrhoeae requires iron and must acquire this nutrient from within its host."
Alright. The time has come to use phages (the natural enemies / predators of bacteria) to combat this kind of infections. Google "phages" on Google videos and you'll find some interesting material on the subject. I myself have done research on phages for years and there's one phage for every type of bateria. Of course Big Pharma isn't going to do research as phages cannot be patented and no money can be made selling them. Of course if you die they (and their stockholders) will mourn the fact that there's one of their benefactors less to contribute to their bottomline.
nice conspiracy theory.
ciprofloxacin doesn't work by binding iron, it works by inhibiting an enzyme in bacteria called DNA gyrase, responsible for unwinding their DNA during replication.
also, your body when faced with an infection, will sequester iron within the bone marrow, to help prevent it's use by the invading organism. google 'anemia of chronic disease' if you need more info.
and finally, iron in our foods has nothing to do with antibiotic resistance. bacteria develop resistance through their own DNA mutations (and several other complicated mechanisms) through which they produce new enzymes (like beta-lactamase) that inactivate or otherwise render the antibiotic molecules useless.
sorry, DNA gyrase relieves strain in DNA strands while being unwound by helicase. its been a while since biochem
there is no cure since antibiotics passed the last round. THIS is the alert message and NOT gonorrea actually. We may have a new way to resolve this by chains of aminoacids but first wait until millons are dead, big farma patent business did its game and than we can cure on 5 USD just all of that and all cancers on top of it.
Answer: I think these guys , as opposed to some conspiracy theorist who cannot even remember sht , know what they are talking about. They say the cipro works to bind and remove iron. Iron chelating antibiotics are presently being used , and since "gonorrhoeae requires iron and must acquire this nutrient from within its host" , means ciprofloxacin most likely works by binding iron. Thusly , predisposal TO catching gonorrhoeae because one has increased iron on board is a real possibility , and carrying around , harbouring disease will be also very high in those with higher iron levels , like meat eaters.
"Ciprofloxacin: a novel therapeutic agent for iron overload?"
"Increased dietary iron could be a risk factor for active tuberculosis"
"Iron-Chelating Activity of Tetracyclines"
"Iron chelation plays a prominent role in the tetracycline management of African trypanosomosis"
As a case in point a very popular malaria drug was found to contain twelve DIFFERENT substances in the drug. Upon close inspection the ONLY portion of the drug which had any efficacy in the treatment of malaria was the PRESERVATIVE they had added to the mix.
"Virtually all activity was m-chlorocresol included as a preservative"