For those who experience debilitating migraines following a glass of red wine, the most likely culprits are congeners, says Leslie Bonci, a registered dietitian and sports nutritionist. These substances occur naturally in most types of alcoholic drinks, including red wine, and give the beverages their distinctive flavors. But certain types of congeners found in red wine, including ones called tannins, can make people who are already susceptible to migraines much more likely to get them. Fortunately, it’s a pretty easy thing to recognize. But unfortunately, most doctors and nutritionists advise people who regularly experience headaches after drinking red wine to avoid it entirely. “If someone says ‘Every time I drink red wine, I get a headache,’ then they really should consider switching to white wine altogether,” says Bonci. White wine doesn’t contain the migraine-inducing congeners that are so prominent in red wine, she says.