Dinglasan's team has found that Plasmodium—at a crucial stage in its life cycle—needs to bind to a protein in the mosquito's gut called AnAPN1. If you block this protein, you block transmission to humans. But how do you treat a mosquito? A teensy needle and steady hands? No. Here's the clever part: You give people a vaccine against AnAPN1, turning them into living mosquito-treatment factories for years; their immune systems produce antibodies against AnAPN1. When mosquitoes bite vaccinated people, they'll suck up the antibodies, which block AnAPN1 so that the mosquitoes can no longer pass along the disease. In lab tests, Dinglasan has shown that the antibodies can indeed make mosquitoes benign—although no less annoying.