The most effective method is a trap, baited with tasty morsels like peanut butter, oats, or dried fruit. Place them along baseboards and walls, where mice prefer to travel, with the bait directly in their path. Simple wood and wire snap traps are a classic for a reason. They work fast, they’re effective, they’re cheap, and they’re reusable. When in doubt, this is a good first option for any home with a mouse problem.