The combination of utter social isolation, eternal confinement in a tiny Mars-One-constructed habitat, the 24-hour surveillance of reality TV, and a lack of mental health services will converge to drive the few dozen people selected to die on the red planet completely bonkers. Even astronauts who know they're coming home eventually can become depressed and anxious in the lonely vacuum of space. Imagine being stuck in a tiny survival pod with only a few people, with transmission delays impeding your ability to keep in touch with people on Earth, unable to travel freely outside on the freezing, barren dustball that is the Martian surface. Forever. Until you die, going down in history as one of the first boldly idiotic explorers of a new world.