This little molecule is what stress looks like.
Researchers from Heptares Therapeutics, a drug company, have discovered the 3-D structure of a protein receptor that mediates our response to stress, according to a new study in Nature. Using a powerful X-ray machine at Diamond Light Source, the UK's national particle accelerator, they were able to detail the structure of CRF1, a find that they say opens up the possibility of creating specially tailored drugs to treat depression and anxiety.
A vital aspect of the discovery is that the receptor has a small binding pocket located in a much different position than other G-protein-coupled receptors, (GPCRs). Knowing the structure of Class B GPCRs like CRF1 could potentially help researchers develop drugs that better target receptors within the same family, Heptares claims. Scientists could just design a drug that pops right into that pocket.
"The finding that the structure of CRF1, a Class B GPCR, is completely different to previously solved Class A receptors confirms why Class B receptors could not previously be modeled for the purpose of rational drug design," said Fiona Marshall, Chief Scientific Officer for Heptares, in a press statement. "Now we know its shape, we can design a molecule that will lock into this crevice and block it so that CRF1 becomes inactive--ending the biochemical cascade that ends in stress," she later told the Sunday Times. The company says it could possibly also lead to targeted drugs for Type 2 diabetes and osteoporosis, since those diseases deal with receptors of the same class and structure.
The discovery is detailed online in Nature this week.
Tristan. I agree that Francisco`s stori is surprising, on monday I got a new Saab 99 Turbo since getting a cheque for $9386 this past 5 weeks and more than ten-grand lass month. it's definitly the most financialy rewarding Ive ever had. I actually started 10-months ago and pretty much immediately startad making over $85 per-hr. I work through this website, ..............zee44.com
hmmm ... i could take a drug for stress ... OR ... i could go on vacation. hmm ...
usually when i go home, I unplug. I turn off my phone, check my e-mail once or twice. Sometimes, just sit in peace and quiet, no music, no TV or radio.
Just me and my own thoughts. feels so good to not endure all the sound pollution.
or maybe I'm just getting old .... dam I'm old ...
Err, Factor, I'm pretty sure they're interested in treating anxiety disorders and depression rather than, "Oh my job is stressful."
For someone with say, SAD, every day can be a living nightmare, and this might be a golden ticket to ending it.
good eye - how the hell did i miss that?
just re-read article. you're right.
i think i need another coffee ....
PS "This little molecule is what stress looks like."
Now, show me what a happy molecule looks like. And, a sad molecule.
They may come up with a drug to mask symptoms like depression and anxiety, but they still won't cure it. Curing it involves getting to the root causes, which are traumatic events in the subconscious mind.
Stimuli, input from your senses, causes the subconscious mind to respond to things which it perceives as dangerous. This forces the conscious mind into abnormal behaviors which we see as mental problems. We then, give them names like depression, SAD, schizophrenia and anxiety. These are clues as to the real problem that the person has. There's nothing physical about it, except what the subconscious mind causes to happen to your physical body, which can number into the hundreds.