Chemical Additive to Antibiotics Could Make Them Newly Effective Against Resistant Bacteria

Bacterial Defense
Many bacteria, like this staphylococcus, have developed resistance to antibiotics over time, but new chemical additive could strip bacteria of their defenses, making old drugs effective once again.Centers for Disease Control and Prevention

Antibiotic resistance is a huge problem, not to mention an economic drain, for doctors and pharmaceutical makers trying to fight bacterial infections. Many antibiotics in our arsenal are becoming practically useless, as bacteria breed resistance to them. But researchers at Texas Tech University and Baylor University have developed a chemical additive that could make old drugs useful again.

Bacterial resistance to antibiotics is a byproduct of natural selection. Antibiotics like penicillins and cephalosporins are generally effective in destroying many common bacteria. But some bacteria have developed an ability to produce an enzyme, known as metallo-beta-lactamase, that renders those common antibiotics ineffective. With overuse and misuse of antibiotics over the past half-decade, the non-metallo-beta-lactamase bacteria have been killed off and the resistant bacteria have been left to reproduce, making them the dominant strain over time.

But the researchers in Texas have developed a chain of nucleic acids, called an aptamer, that stops metallo-beta-lactamase enzymes from breaking down antibiotics. Aptamers themselves are not new, but these particular aptamers bind to the enzymes, rendering the bacteria's defenses impotent. As a result, even older antibiotics, in conjunction with the right aptamers, should be able to destroy bacteria that previously were resistant.

Pre-clinical trials on the aptamers are already getting underway. If successful, the use of aptamers alongside standard classic antibiotics could rejuvenate efforts to destroy infectious bacteria in places where it's been either impossible or far too expensive before.