There Are Way More Blood Types Than You Think

It would be cool, if they discover when they RH negative bloods began. 85% of us humans can breed with each other, but if a mother who is RH negative has a RH positive baby, her body will kill it fetus. How in the world in the human species did that occur?

Also before science could identify the various blood types and RH positive and negative people, how did the RH negatives people begin and avoid mating with the positives? Human wise, we all look human and you can see from the outside the various blood types.

If a RH negative person began as a mutant, then the first time it mated with a positive, which is everyone else, it should of ended the species right then. It is really a curious odd part of the human species. It does not make sense.

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Science sees no further than what it can sense.
Religion sees beyond the senses.

Imagine 10,000 years ago, 100,000 years ago, 200k or more a tribe ventures of to a new land. Once they arrive will they spontanously start producing RH negative babies, no. If one mutant RH negative baby is born, it can't successfully mate with anyone else in the tribe; its a dead end street.

The only way to continue the human species with RH negative, is if all of sudden a large quantities of humans with RH negative have to showed up at the same time. Now how did that happen?

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Science sees no further than what it can sense.
Religion sees beyond the senses.

A twin who mated with each other maybe?
Apparently it isn't that difficult to achieve, because it happened 32 times already.

@Robot: The complications from an Rh- mother gestating an Rh+ fetus do not cause termination of the pregnancy...the first time. Her immune system is sensitized to the Rh factor antigen and she will have an immune reaction to a second Rh+ fetus. But if she is Rh-, she passes that gene on to her first viable offspring. The gene gets into the population through her first child. This will increase the incidence of that gene. And I believe (I am not a geneticist) that there are a large number of alleles that all amount to Rh-. That suggests that many mutations arose independently, each resulting in a non-functional protein. So multiple versions of Rh- get into the population and eventually they result in homozygotic recessives, negative blood types.

ravenbrand,
This is excellent information and I really appreciate it. I imagine a lot of people were expecting me to go off on an outer space alien intervention of dna and created the RH negative blood type humans. I really do not think that.... nope.

I think the outer space aliens screwed with all the humans in different ways and help the humans come into being from the monkey. But hey, that is another story. ;)

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Science sees no further than what it can sense.
Religion sees beyond the senses.

If you could imagine life in the COSMOS somewhere that is 1000 or 10,000 times more advance than we are on the Earth.

Now imagine if your planet had a need of materials of dire nature and so you sent space craft and probes into the COSMOS to find what need was and acquire what you need and signal back to the home world that you have what is needed.

Now as a space craft approaches planet earth long ago, it has long since left the point of return to its own planet. It had gone past the point of halfway. Earth was considering on the edge of its ability of searching from the home world.

So it had used up its cosmic energy for long range space travel, but had still all its technology, science, abilities and abundance of short term flight and energies and yes they care weapons too.

These aliens do have the ability of long term health in terms of 10 to 100 thousand years of earth time. They can repair themselves easily. Remember, their technology is 1000 to 10,000 more advance than ours on Earth. So once the outer space aliens landed on earth, they had the ability to be hear a long time easily.

So the aliens landed on earth and acquired the raw materials they needed. They aliens are spoiled to being advance life and eventually lose the interest to continue acquiring these materials and revolt to the higher authority to make help with the local animal life. So they started tweaking and malipulating around with the DNA of the local animals. The found one particular animal most useful and tweak the monkey gene and we humans were born. Still in the tweaking of this was not perfected immediately and as humans become socially, politically and visually aware of the world around them much politics for the aliens occurred too. Wars even happen upon many groups of the aliens across the world of earth and atomic and laser type weapons were used.

Now an interesting to notice from our NASA and world observers is we as a society had gotten really excited and interested in what we saw in the land scrape of Mars and thought we found a pyramid of sorts or a carved face in the land scrape.

Now imagine you are an alien race, stranded on a planet, acquiring raw materials for the home world and yes you do want to be found and go home. One of the best ways to be found is to create monolithic structures all across planet earth that do not conform to the natural environment and if you have a advance alien race observing the planets from far away, say Orion, they may seen straight lines, angles, pyramids, circle structures on planet earth. Yes this would be a flag, a signal to become interested. In all this signally from planet earth was a message as well from the children asking for mother to come and get them.

Finally keep in mind, the home planet come and got the aliens and took them home. Yes there was alien political problems a mess they left on earth, humans were destroyed, animal life destroyed, social behaviors guided to the correct direction, others left behind on earth. Earth is still considering a remote planet, extremely far away from the home world. They do not visit us often. They do visit us and yes they do continue to guide human culture, tweak with human dna and yes they will return again.

There is a lot going on in the COSMOS in activity and we are not alone. Still we have purpose or we be destroyed and replaced. So in that I think there is always hope.

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Science sees no further than what it can sense.
Religion sees beyond the senses.

Wow, I guess men have commented here only! Well, I am 0-, Rh negative. I have three children all are 0+. At 28 weeks I got a a shot call rhogam. It helps my blood cell not attack the fetus. I also had another right after giving birth, with-in 24 hours. But If I hadn't got the immunological shot there might have been a possibility that my body would of rejected fetus the SECOND time I was carrying a baby. They have had the shot around since the late 60's. But what do I know I am just a female and have had two pregnancies (twins and a singleton).

goswick33,
I am sure you are intelligent and know a lot. You are obviously mature and intelligently to face and deal being O- and being pregnant with 3 o+ babies. And as you said they had medicines to help since the late 1960s.

Now, how did the RH- start and maintain itself prior to medical science have the ability to identify blood types? You explanation does not answer that.

The best explanation so far was from ravenbrand. He explains that a woman’s immune system often will tolerate once to term the first pregnancy, which seems in the great quantities of humans across the planet seems reasonable enough. It must be in the realm of human immune tolerance to some extent; else 15% of the population would not exist.

By the way, I am O+ too. When I was born, I had immature immune system and was rushed to the hospital 100s of times, until the age of 5 and it matured. A great many of those times I was near death as a baby!

GOD BLESS MY Parents!!! You and yours and faithful loving parents EVERYWHERE!!!!!!!!!
I LOVE YOU MOM AND DAD!!!!!!!!!!!!!!!!

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See life in all its beautiful colors, and
from different perspectives too!

Ok I tried this before and it all disappeared, so here goes try number to clear up some of these questions regarding RH positives and negatives and RH in general. Sorry this will probably be a bit long.

Well I guess I should start out by explaining the genetics of it. what what call RH positive/negative refers to the presence of an antigen on our red cells that we have come to call the D antigen. 85% of the population has this D antigen so we call them RH positive, while 15% of the population do not have it and we call them negative. If you have it, your positive;if you don't, your negative. because of this, RH D works like a recessive trait. To be negative you must have been given to alleles that were negative for the RH D gene. (an allele is a different form of a gene. think ABO blood types which have an allele for A, for B and O) if at least one of your parents pass you a D positive allele you will be positive. To be negative you need to get the negative allele form both parents.

So more then likely because RH D neg is a deletion, it likely only occurred to a single gene that was passed on. so the first person to have the D Neg gene would actually be D pos. this person is said to be heterozygous because they have two different alleles (positive and negative) for the same gene. when this person mates, they will give either the positive allele or the negative allele. so this first parent will begin passing on the negative allele for probably generations (assuming no intermarriage) before two heterozygotic (+/-) parents produce a negative child (only a 25% chance)

This first D negative baby could be either male or female. If it was a male their wouldn't be any kind of problem. If he mates with a homozygous woman their kinds will all be heterozygotic. If he mates with another heterozygote their kinds would could be either positive (+/-) or negative (-/-).

No problems would occur until a D neg mother has a positive child. as mentioned though it is usually not until the second child that there is a problem. unlike ABO antigens the body doesn't normally produce an antibody to the D antigen. When the mother gives birth there is bleeding that takes place which allows the some of the babies cells to enter the mothers blood stream. when the mothers body sees these cells it reacts to it like it would to anything it sees as foreign like a bacteria or virus, it creates an antibody to it which we call anti-D.

so when the next D positive baby comes the mothers anti-D crosses the placenta and attaches to the baby which will cause the baby to be sick possibly to the point of death. but usually only 5% or unavoidably fatal. most will suffer a varying degree of sickness which may or may not still be fatal. it really depends on what the level of antibodies in the mother which will increase (and therefore be worse on the baby) with each positive child.

Because of Rhogam this isn't usually a problem anymore. the ironic thing though is that Rhogam is actually anti-D. The Rhogam however isn't enough to adversely affect the baby, as the dose is low But when the baby's cells enter the mother blood stream, the Rhogam works to get rid of these cells so that the mother's immune system doesn't detect them and produce it's own antibodies.

Depending on how strict the blood bank is when typing blood, some people can appear to be D neg when they're actually D pos. This is now called Weak D (it used to be known as being Du Pos). This can happen for a couple of reasons. Sometimes another RH antigen called C (said Big C) can decrease the expression of the D antigen. Other times the number of D antigens present on the cell is decreased. Finally someone could be a mosaic where they have only a part of the D antigen. Only the latter is of true importance as a mosaic can form antibodies against the part of the D antigen they don't have. Since it is too difficult to determine if they're mosaic or not, those with weak D are treated as a Negative for the purpose of receiving blood and Positive for Donating.

As mentioned above there are other type of RH antigens. Most are rare or rarely clinically significant. The most clinically significant RH antigens are D, C/c, and E/e. These 3 sets of antigens are produced by 2 genes. One, called RHD, produces the D antigen, while RHCE produces the Cs and the Es. These two gene are very close on the chromosome and until recently there was a large debate over if the three antigens were produced by 1 gene or 3 different genes. There are 8 different antigen combinations possible: Dce, DCe, DcE, DCE, dce, dCe, dcE, & dCE. The letters D, C and E were chosen by those who believed the antigens were produced by 3 different genes. Those that believed there was only 1 gene used a different naming system based on the 8 different combinations. The Most common combinations are DCe, DcE, and dce, also known by the other system as R1, R2, and r. After the D antigen, the C/c and E/e antigens are the most antigenic in the RH family.

Wow that was a lot! Sorry for the length, but i hoped that helped.