In 1997, Jeanne Louise Calment of France died at the age of 122, making her the oldest documented human to have ever lived. People who live to be 100 years or older are rare, and only about 1 in 600,000 people in industrialized nations live that long. But is there something genetically unique about centenarians that enables them to age gracefully and relatively disease-free? According to the results of a long-term study at Boston University School of Medicine, the answer is yes.

Jeanne Louise Calment Lived to Age 122:
As part of the New England Centenarian Study, a team of aging research specialists led by Paola Sebastiani and Tom Perls looked at 300,000 genetic markers in 800 centenarians and compared their profiles with those of random individuals. They then developed a genetic model that can compute an individual's predisposition to living a long life and found that centenarians shared a common genetic signature that could predict extreme longevity -- with 77 percent accuracy. The findings represent a breakthrough in understanding how genes influence human life spans.

"Out of 100 centenarians we could correctly predict the outcome of 77 percent, while we incorrectly predicted the outcome of 23 percent," said Sebastiani. The researchers believe the 23 percent error rate can be attributed to genetic variance not yet known and included in the analysis, as well as other factors that influence longevity. "Making healthy lifestyle choices such as eating a well balanced diet or exercising regularly and avoiding exposure to tobacco plays an undisputed role in determining how each of us will age," said Andrew Sugden, international managing editor of Science.

Centenarians are a model of aging well, and 90 percent of people who reach this milestone are disability free at the average age of 93, Perls said. But he advised caution about the possibility of "testing" people to determine longevity, saying that much more study needs to be done regarding how health care providers and the research community guide individuals about what to do with the information they get. "I think a test for exceptional longevity is not quite ready for prime time," he said. "We're quite a ways from understanding what pathways governed by these genes are involved and how the integration of these genes, not just with themselves but with environmental factors, are all playing a role in this longevity puzzle."

According to Perls, future analysis of the results may shed light on how specific genes protect centenarians from common age-related diseases, such as dementia, heart disease, and cancer. "I look at the complexity of this puzzle and feel very strongly that this will not lead to treatments that will get a lot of people to become centenarians, but it could make a dent in the onset of age-related diseases like Alzheimer's," he said.

The results of the study were published today on the Science Express web site.

11 Comments

Add 30 years of research and I'm sure these guys will be singing a different tune. Or be dead :-/

A_Rock, FYI, I'm writing a book on anti-aging science with one of the leading scientists in the field. In 30 years, 150 will be the new 30.

Science has the knowledge today to extend human life well beyond the theoretical 125-year limit. In less than 30 years, that knowledge will be available to us all. By 2040, we'll all be enjoying the benefits of virtually indefinite life spans.

@paulhebner: If we look at the rate of medical advancement, your post looks alittle ahead of its time...

@Paulhebner I'm actually in complete agreement with you but I try to maintain conservative posts.
I'm actually extremely excited about it! There is a lot people don't take into consideration when looking at the medical trends of the past and then trying to predict the medical advancements of the future. All that stuff aside (I'm sure I would be preaching to the quire here) I can't wait! True longevity and youthfulness would solve all of our --well most of our-- world problems. Not complicate them like so many people think. Investments in: relationships, travel time, family, risk taking, ridiculously long travel time, work, retirement, the planet (you'll be here longer), housing, communities, governments! We'll want to have more permanence and sustainability in everything we own! Our governments will be held to a higher level of accountability! You can educate yourself in whatever you wish for as long as you want and then learn something else. Why? Time! Travel to the stars will be more then possible if you don't die! Terra-forming will become a reasonable topic because we'll be alive when it's done. What's 200-500 years working on a project when you have thousands of years to enjoy it when you're finished. There's still no such thing (as I currently understand it) as "true immortality". The universe will end eventually or a big rock could land on your face. So everyone might as well leave any god or religion out of the concept. You die. Anyways I'm sorry, I've had my imagination tickled ^.^ I could go on and on and on about this stuff lol

@paulhebner
I'm going to bring a little realism to the table.
I really really really really really doubt we will be extending our lives past 125 in the next 30 years.
If the guy you were talking to was a leader in the field wouldn't he be working his ass off to make these sorts of medicines possible?
Based on what I've seen medical advances are slow compared to technological advances. Maybe it's because to test these advances you need human lives. Maybe it's because people are too busy buying snake oil instead of real medicine or real medicine is the snake oil sometimes.
Anyways until they can extend a normal persons life 20 years 80->100 or for that matter at all I really think your estimates are off.
BTW they've been saying the same for the past 20-50 years soooo, it's basically like nuclear fusion if you know what I mean. ;)

@paulhebner
I'm going to bring a little realism to the table.
I really really really really really doubt we will be extending our lives past 125 in the next 30 years.
If the guy you were talking to was a leader in the field wouldn't he be working his ass off to make these sorts of medicines possible?
Based on what I've seen medical advances are slow compared to technological advances. Maybe it's because to test these advances you need human lives. Maybe it's because people are too busy buying snake oil instead of real medicine or real medicine is the snake oil sometimes.
Anyways until they can extend a normal persons life 20 years 80->100 or for that matter at all I really think your estimates are off.
BTW they've been saying the same for the past 20-50 years soooo, it's basically like nuclear fusion if you know what I mean. ;)

@webguy you make a valid point and one that is brought up quite often. Human testing and approved sale for any new medical product takes a very long time. What will be one of the first major breakthroughs--we've already seen some fruit come to bare on this-- is artificial human testing and advanced computer modeling for drug testing and manufacturing. Just trust me. Computers are really the key here. Where since the 50's people have been toting about how all our ailments will be cured. They really didn't have anything to base that theory off of besides how fast medical advancements seemed to be coming along (few people knew much about genes or computers at this point). We are all aware those early to late 20th century predictions were wrong. Whereas in our current day and age we have access to mind numbing amounts of relevant information on medical topics, discoveries and progress. Multiple dramatically different fields of science are converging in a way that will really throw you for a loop. In our genes is the software that runs the hardware of our biology. Not now but sooner then you think we will be able to re-write and re-program our own software, effectively removing the genetic trait for ageing and death. From there it's "be careful" until we can make ourselves stronger and more durable as well. The first big leap will be getting our bodies to want to continue renewing themselves as long as we take care of them. Then POOF you're just a stones throw away from relative immortality :D I'm sure I haven't convinced anyone of anything. Just please. Remember I said it ;)

It's very strange that there is no stupid religious comments on this article!

well if indefinite lifespan was achieved in the next 30 years- not saying it won't be (Nanobots? Telomerase?), short term I don't think it'd be a great thing for the planet. Long term, I believe it'd really slash birth rates (with indefinite youth, why reproduce so much to carry on your legacy?) and would totally redefine human existence. Needless to say religious groups would probably despise or condemn this. Still, after a while, I think we'd get a better society.

@dustin Yeah the short term would probably be chaos lol Everything would need to change and things generally don't change smoothly. Also you'll notice that in developed countries most people are already having dramatically fewer children. Survival rates are higher and kids are pretty expensive nowadays. It would actually be a nice change of pace knowing you could have one child, finish raising him/her, then have another one. If that's what you want to do. In theory if we had no expiration date we could have a kid every 100 years.
And yeah religious groups generally have a problem with anything that seems to get in the way of "God's plan" (please no one take offense to this) But every time I look at what people have said god wants throughout history, it's always what seems to have been normal at that time. I think if god didn't want change he wouldn't have let us come into existence. Or made my hands so they fall ever so conveniently and effortlessly on my crotch. Not sure if that's relevant but it's funny!

The unending researches and studies of scientists have resulted to the countless innovations in Science and Technology. These are all evident nowadays. As time goes on, new finding arises until another invention is born. Two brand new improvements in Science have introduced the potential for biological computers nearer than they have been before. Biological transistors and skin-based touchpads have now been developed and even tested. In a paper published in the journal Nature Communications, the Imperial College in London announced that a team had created biological transistor gates. DNA alterations on E.Coli viruses created logic transistors that are able to open or close based on a true-false electrical signal — the basis of binary code. The E.Coli viruses used to create these transistors are all normally found in the human digestive system and would theoretically be compatible with the human body. Resource for this article: Two new developments bring biological computing closer than ever


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