It's dangerous, of course, to take increasing amounts of medication for a particular condition. It's hard on the organs; and that's in addition to the stress the condition puts on one's body in the first place. No one is sure exactly how many cases of high blood pressure might be medication-resistant, because this kind of resistance is relatively new. But a review of past hypertension studies suggests that the numbers could be as high as 30% of all patients who report high blood pressure. It joins diabetes and heart disease among the worst complications in the ever-worsening problem of obesity in this country.