PopSci Predicts: The Year Ahead

We'll get a vaccine for addiction, debate the future of nuclear power, use new tech to take on water shortages, and-just maybe-find an extra dimension or two. Happy New Year

For an illustrated month-by-month calendar of the science stories to watch for in 2007, click ‘View Photos’ at left

**The Answer Machine Arrives
**

The world´s most powerful physics laboratory will take on questions we can´t yet imagine

Later this year, the $8-billion science experiment known as the Large Hadron Collider (LHC) will start uncovering clues to some of the biggest mysteries in physics. It was designed more than a decade ago to answer a specific checklist of questions: Why does matter have mass? Does every particle have an unseen partner? In the intervening decade, however, physicists have been developing new ideas about how the universe might be put together. If all goes well, the machine-a 16.8-mile-long proton smasher buried outside Geneva, Switzerland-could discover startling phenomena that could validate (or refute) those nascent theories about the origin and structure of the cosmos.

Jonathan Feng, a theoretical physicist at the University of California at Irvine, has suggested that collisions at the LHC might produce dark matter-the mysterious, invisible stuff that astronomers believe makes up 80 percent of the matter in the universe. This is not something the original planners had in mind. â€The idea that the LHC would help with the big cosmological questions was completely off the map when it was proposed,†Feng says.

The same holds true for the search for extra spatial dimensions, which for years were thought to be out of the reach of modern experimental technology. Recently, though, theorists have discussed the possibility of finding indirect proof at the LHC. â€You´re not going to see the extra dimensions,†says physicist Konstantin Matchev of the University of Florida. Instead, he explains, particles such as electrons will suddenly become more massive as they travel through that added space. Matchev and his colleagues will be scouring the data for those telltale weight gains.

But even if the LHC fails to reveal either of these events, it should still be a tremendous success. The discovery of the Higgs boson, the â€God particle†that may give matter its mass, is a near guarantee, according to most physicists. More important, the LHC is going to generate conditions and energy levels that haven´t existed since the big bang. That means it could produce phenomena physicists never even thought to imagine. â€The great thing about science,†Feng says, â€is that you never know what Nature has up her sleeve.†_-Gregory Mone
_

** Supersizing the Space Station
**
_The deadline: 2010. The key year to meeting that deadline: 2007
_

When the space shuttle Columbia disintegrated in 2003, only 49 percent of the International Space Station´s intended hardware was in place. The disaster led to the shuttle´s mandatory retirement in 2010 and, in so doing, created a hard deadline for the completion of the $100-billion ISS. If the orbital construction project is ever going to be the world-class research facility and moon/Mars stepping stone scientists first envisioned two decades ago, 2007 will be a very busy year indeed.

NASA has scheduled 14 more assembly missions to complete the ISS, five of them this year. If all five prove successful, by this December humanity´s only outpost in space will be 30 percent more massive, have 5,000 more cubic feet of space, generate nearly triple the power, and, most remarkably, boast two new state-of-the-art science labs.

Europe´s Columbus Lab and the Japanese Experiment Module (nicknamed Kibo) are the coming year´s marquee payloads. These billion-dollar bus-size modules will greatly expand the outpost´s research capabilities in terrestrial science (drug development and climate study, for example) and in work vital for long-duration missions to the moon and Mars, such as space medicine and radiation shielding. Also on the manifest: a Canadian-built robot called Dextre, for Special Purpose Dexterous Manipulator. Once permanently affixed to the station, Dextre will use its two 11.5-foot-long, seven-jointed appendages to perform intricate repairs that would otherwise require spacewalks, giving astronauts more time to spend in the new labs.

This year´s efforts will be the most challenging series of space missions ever attempted-â€even more complex than Apollo,†says NASA spokesperson Allard Beutel. Given the troubled track record of both the ISS and the shuttle, it´s not surprising that many doubt the agency´s ability to pull it all off on schedule. â€The station and shuttle are always surprising us with new problems. The plan is not going to go right by the book,†warns Louis Friedman, director of the Planetary Society. â€It is very unlikely that we´re going to have that many successful flights on so tight a schedule. If we do, we´ll be lucky.†And we´ll see the troubled station become the long-promised training ground for the next generation of space travelers. -Rena Marie Pacella

** The Year’s Top 5 Space Launches
**

  1. Themis Probes
    On January 21, NASA will send five small spacecraft into the heart of the violent geomagnetic disturbances in the Earth´s magnetosphere. The goal: to uncover how magnetic substorms in the region cause the colorful northern lights.
  2. China´s Chang´e 1
    China´s first lunar orbiter will kick off the country´s ambitious moon program on April 17. During its year in orbit, the instrument-loaded probe will survey the lunar surface to prepare for an upcoming Chinese lander mission.
  3. Dawn Spacecraft
    On June 21, NASA´s ion-propelled Dawn will take off for the asteroid belt between Mars and Jupiter, where it will study the two most massive space rocks in our solar system, Vesta and Ceres, which was recently promoted to dwarf-planet status.
  4. Phoenix Mars Lander
    The low-cost NASA spacecraft will blast off toward the martian arctic in August to look for signs of life (present or past) in the ice that lies just beneath the Red Planet´s surface.
  5. GLAST Telescope
    On October 7, the Gamma-ray Large Area Space Telescope will launch into orbit and begin to observe our universe´s most fascinating phenomena, including black holes, quasars and neutron stars.

** Stem Cells Grow Up
**
_ New research into adult cells may reenergize therapeutic research
_

The promise remains tantalizing: radical new treatments for diabetes, Parkinson´s disease and even cancer enabled by stem cells-self-renewing bodies capable of differentiating into other, more specialized cell types. Progress, however, has been achingly slow. The California Institute for Regenerative Medicine, which administers the state´s $3-billion stem-cell-research initiative, estimated in October that fully developed stem-cell therapies are still more than a decade out.

Why the wait? Scientists need a far deeper understanding of cell biology, where the bulk of research will be focused for years. And even that task is hindered by laws proscribing the use of human embryonic-stem-cell lines in federally-funded labs.

Small wonder, then, that the most enticing developments are coming from research on adult stem cells-a twist that could render moot the moral objections associated with the use of embryonic cells. Adult stem cells, which regularly repair or replace damaged cells, have been hard to morph into other types of tissue. But that´s changing. Last year, researchers at UCLA transformed adult stem cells in fat tissue into muscle cells, a development that could aid in repairing arteries and bladders.

Even more groundbreaking was the work by two scientists at Kyoto University in Japan who reported last August that they had induced embryonic stem cells from adult skin cells in mice tails. They first isolated four genes present in embryonic cells but inactive in adults. When adult cells received chemical factors from those four genes, they reverted into embryonic cells that could differentiate into any tissue. If the Kyoto research is replicated in humans, it will be a game-changer for the science. â€Let´s say you could take your skin cells and reprogram the nucleus to create an embryonic-stem-cell line-without an egg,†says the California Institute´s Mary Maxon. â€Therapeutically, that would be huge.†-Kevin Kelleher

** Fighting Water Woes
**
_ As global shortages grow, the U.S. turns to high-tech solutions
_

When three drunken white men drove through the Native American village of Chiloquin, Oregon, in 2001, blasting a portable toilet with a shotgun and yelling, â€Sucker lovers, come out and fight!†locals got an Americanized taste of the conflict that might dominate the world´s next century: water wars. Irrigation had been cut off to protect endangered suckerfish, considered sacred by the Klamath tribe. As resulting droughts pitted area ranchers and farmers against tribe members, water was becoming a bargaining tool in Uzbekistan and Gaza, a military target in Lebanon, Nepal and Darfur, and a catalyst for riots in Somalia, China, India and Pakistan. â€There´s always been conflict over water,†says environmental scientist Peter Gleick, whose Pacific Institute in Oakland, California, compiles a list of flare-ups dating back to 2500 B.C., â€but the tension is growing.â€

The U.N. estimates that by 2025, five billion of the world´s projected 7.9 billion people will lack access to safe water. Although the most dire crises will certainly be outside our borders, in the U.S.- where the population just surpassed 300 million, water-storing snowpacks are melting in a warming climate, and people use more water per capita than anywhere else (up to 100 gallons a day)-conditions are ripe for conflict. Our aquifers are draining faster than they can be replenished, and the biggest, Ogallala, which stretches from South Dakota to Texas, has seen localized drops in the water table of 150 feet. Seven Western states are stuck trying to wring more water from the drought-ridden Colorado River, which is already reduced to 0.1 percent of its volume by the time it reaches the Gulf of California.

Enter desalination. The world´s largest inland plant, an $87-million, 27.5-million-gallons-per-day (MGD) project in El Paso, Texas, will make brackish groundwater potable starting this year-just as the country´s first large-scale seawater plant, a troubled 25-MGD facility, finally begins operations in Tampa, Florida. In Arizona, a test reopening of the mothballed Yuma Desalting Plant may mitigate Colorado River losses, and in California as many as 20 desalination projects along the coast will be debated. The fate of the biggest plants, two 50-MGD facilities in Carlsbad and Huntington Beach, could be decided by this summer.

Electricity-hungry desal plants are becoming more economically viable because of advances in water-purifying reverse-osmosis membranes, tens of thousands of which are contained in a large plant: The newest can produce upward of 10,000 gallons a day apiece, up from 5,000 gallons in the late 1990s. Composite materials may soon double a membrane´s life-10 years rather than five-and nanotube-based membranes will shorten the length each water molecule must travel. â€If this happens, plant productivity will go up 20 times,†says Nikolay Voutchkov of Poseidon Resources, the company behind the Carlsbad and Huntington Beach projects. â€It´s like having a vacuum-tube computer, then switching to the microprocessor.†The company´s vision for the future doesn´t stop there. If the Carlsbad bid goes through, it plans to engineer the city´s tap water to have the mineral content and taste of Pellegrino bottled mineral water.

Gleick, meanwhile, cautions that desalination is a supply-side solution to a demand-side problem. He wonders if the price tag and environmental effects-marine kills during intake, discharges of hypersaline brine-are worth it. Indeed, the best solutions to the coming water crisis may be as mundane and varied as low-volume-flush toilets and drought-resistant crops, especially in the developing world, where funds for Pellegrino-spitting facilities are as scarce as water itself. -McKenzie Funk

** The (Not So) New Nuclear
**
_ Despite resurgent interest in nuclear power, novel plant designs stall
_

It´s been 33 years since a nuclear power plant was commissioned in the U.S. That´s likely to change by later this year, when the Nuclear Regulatory Commission could approve a site for a new reactor on American soil. Lured by government incentives, and backed by environmentalists pushing nuclear as an emission-free alternative to fossil fuels, 15 power companies have announced their intention to build new U.S. plants within the next few years.

Nuclear now supplies one fifth of our power, but Americans´ appetite for energy is growing-some estimates project a 40 percent jump in consumption by 2030-and our current plants are getting older. Although the next wave of reactors will supply some of that juice and fill the voids left by decommissioned plants, they won´t be transformative. There are new reactor designs, but most of the updated features are safety-related; these plants won´t support hydrogen production, for example.
This May, however, the Department of Energy will select one of three new designs for a truly next-generation nuclear plant, with the goal of building a commercially viable version by 2021. Each of the proposed designs would generate temperatures in excess of 1,650

MARCH: POOLING TALENT AT THE POLES

More than 50 countries will send expeditions to (and focus their satellites on) Earth´s remotest regions during the fourth International Polar Year, which begins in March. By coordinating observations and analysis, scientists will gather extensive data that could lead to a new understanding of melting ice caps, the depleted ozone layer and thinning permafrost. They will also conduct some of the most detailed surveys of marine ecosystems and polar wildlife ever undertaken.

MARCH: WANT MORE TIME?

You got it. Clocks spring forward three weeks early (on March 11) and fall back a week late this year. Although the extra month of Daylight Saving Time, a shift mandated by the Energy Policy Act of 2005, should save the energy equivalent of 100,000 barrels of oil a day, it may also trigger glitches in consumer gadgets and computer networks.

DECEMBER: FLARING UP

By the end of the year, the sun will be heading into a new season of solar-storm activity, expected to be the most intense in half a century. Solar storms, which often spew bubbles of hot plasma toward Earth, can fry satellites, down power grids, and put astronauts´ lives at risk.

NOVEMBER: MANTLE MUNCHER

Japan´s Chikyu, a floating lab that doubles as a deep-sea drill, sets sail for its first mission this fall. The ship will bore thousands of feet into the seafloor to study earthquake-generated tsunamis. Its ultimate goal: to pierce Earth´s mantle.

MAY: CORN-FED INDY

On May 27, more than 30 650-horsepower racecars will zip around the Indiana speedway of the Indy 500 at more than 200 mph, fueled by domestically-grown corn. Equipped with Honda´s new 3.5-liter V8 power plants, all IndyCars in this year´s racing season will run on 100 percent fuel-grade ethanol, a first for a major-league motor-racing series.

FEBRUARY: HURLING NEW HORIZONS

Thirteen months after its launch, NASA´s New Horizons spacecraft flies within 1.4 million miles of Jupiter (that´s more than four times as close as the Cassini craft got in 2000). The piano-size probe will get a huge gravity boost from the gas giant that will slingshot it toward its destination-the dwarf planet Pluto-and shave up to five years off its trip.

JANUARY: BUENA VISTA?

When it comes to the operating system that will replace XP, Microsoft seems like it has always been-and always will be-developing and testing and fine-tuning and debugging and, well, delaying the launch of Windows Vista. The company´s latest official word on when the system will ship to consumers: this month.

JANUARY: THE AUTO SHOW AT 100

At a local beer garden in 1907, spectators paid 50 cents admission to see 76 shiny new gas-, electric- and steam-powered cars in the first-ever Detroit auto show. This January 7, some 700 production and concept cars from around the world debut at the longest-running car show in North America.

JUNE: TEACHER IN SPACE

Seven astronauts will crew the space shuttle Endeavor´s 11-day assembly mission to the International Space Station in June. Among them: Barbara Morgan, initially trained as the backup candidate for the ill-fated 1986 Challenger mission. Morgan, 55, now a fully trained astronaut, has waited two decades to become the first teacher in space.

NOVEMBER: OSPREY ACTION

After decades of troubled development, the first squadron of V-22 Ospreys-the military´s tilt-rotor aircraft that can take off like a helicopter and fly like an airplane-becomes fully operational. Marine Corps squadron VMM-263, also known as the Thunder Chickens, will fly the planes, providing supplies and combat support to ground forces fighting overseas.

JULY: ANDROID ATHLETICS

On July 2, World Cup soccer kicks off in Atlanta-World Cup robot soccer, that is. For six days, hundreds of autonomous athletes, ranging from Sony Aibo dogs to dwarf-size humanoids, will converge on Georgia Tech to battle it out in one of the biggest robotics competitions of the year, the RoboCup World Cup. The aim of the annual games is to create a team of soccer ´bots smart enough-and coordinated enough-to beat the human world-champion soccer team by 2050.

JULY: TRANSFORMERS: THE MOVIE

Planet Earth is the front line in the epic battle between Autobots and Decepticons when director Michael Bay´s live-action movie Transformers opens on July 4. Based on the animated series and popular action figures of the early 1980s, Bay´s Transformers (brought to life by CGI) can change from, say, a 25-foot humanity-hating robot into a deadly jet fighter in four seconds flat.

SEPTEMBER: GET READY TO PLAY GOD

Legendary videogame creator Will Wright (of Sims fame) revolutionizes gaming again with the wildly anticipated Spore, due for release by early fall. The player starts with a single-celled creature and guides the ever-evolving species through six stages (or â€levelsâ€) of life, from the tide pool to the big city to galactic domination. It´s survival of the fittest at its digital extreme.

MARCH: GOING DIGITAL

Although there are still two years to go before the Federal Communications Commission imposes the death sentence on analog TV, the decade-long transition to digital television is about to get a long-awaited boost. By March, all TVs sold in the U.S. must be capable of receiving digital signals, per FCC mandate. With more people able to tune in, expect more stations to deliver the DVD-quality sound and picture of digital programming.

OCTOBER: AIRBUS ARRIVAL?

In late 2006, instead of delivering the twice-delayed A380 super-jumbo jet to its customers, Airbus announced yet another lag-the first A380 will not be delivered until this October, 20 months late. Curiously, the company called this delay â€a delivery schedule our customers can count on.â€

OCTOBER: RACING ROCKETS

The Rocket Racing League takes off in Las Cruces, New Mexico, as the first 10 pilots push their rocket-powered craft to 300 mph around a mile-high virtual track. Fans can watch as the speedsters take 500-foot plunges over the grandstands, or follow the planes on six 50-foot video screens, each with the 3-D track superimposed over the race.

NOVEMBER: DRUGGING OUR DIET

French company Sanofi-Aventis´s highly anticipated diet drug, rimonabant, which cuts cravings and improves fat metabolism, became available to Europeans under the name Acomplia in 2006. Many expect it to pass muster with the FDA before the end of the year-and be prescribed to the ample market of overweight Americans in vast quantities by 2008.

MAY: VENUS MATES

While on its lonely, seven-year journey to Mercury, NASA´s Messenger probe will have the rare opportunity to rendezvous with another craft, Europe´s Venus Express. Together the two will learn far more about Venus´s toxic atmosphere than either could have done on its own.

MARCH: iPHONE CALLING

Obsessive Apple-watchers have been buzzing about a so-called iPhone for years. While Apple refuses to issue any official confirmation of its existence, anonymous accounts from company insiders detail the development of a mobile phone with an iPod-like design, a three-megapixel camera and wireless service provided by Cingular. If the rumors are true, we could be dialing different by early this year.