I've been testing out my mostly neutral stride in the Nikes the past few weeks, and my conclusion is: They're fine. I don't feel any more or less pain, or any faster or slower, than I do in my other shoes. Which is not to say there aren't differences: They are remarkably light, yet I found myself clomping along like a Clydesdale, because, I suspect, the shoes are pretty stiff (and because I tend to clomp). Also, they have a very bright orange sole that made me feel like I was cheerfully running on a layer of Orangina (but just made my girlfriend laugh out loud). But I didn't feel a lick of difference in the pronation support as compared to my Saucony ProGrid Guide2s or Mizuno Wave Creation 11s.