How this virus manages to continually invoke change has been a hot topic in virology since the mid-1930s when one of the pioneers of flu research, Richard Shope, discovered flu had the ability to switch hosts from pigs to mice. After the discovery of DNA in 1944, research focused on how influenza could change its genetic code to move from one animal to another and eventually to the human. Over the years, the mechanisms were found and as far back as the 1970s, there was a clear appreciation that evolution equated a potential emergency. Thankfully, much like human resolutions, the majority of flu adaptations could not be sustained and innumerable virus strains disappeared. However, when an evolutionary change was stable, the result was not only a novel flu strain but also as seen in 1918, 1957, 1968 and 2009, a pandemic. Worse, as was seen in the latest global outbreak, mutation was not only limited to one per year, but potentially after each and every infection.