• Science

    Discovery of a "Transsexual Gene" Raises More Questions Than Answers

    By Julia Wallace Posted on 11.18.2008 4 Comments

    A few weeks ago, Hanna Rosin's wrenching and well-researched article about young transsexuals—including a girl named Bridget (née Brandon), whose first words were "I like your high heels"—zipped around the blogosphere. In it, Rosin discusses the unsettling work of a psychiatrist who questions the scientific basis for allowing children to "transition" to the gender of their choice, citing several kids who emerged from their gender dysphoria after a rigorous course of therapy. "If a 5-year-old black kid came into the clinic and said he wanted to be white, would we endorse that?" he asks. The prospect of letting pre-pubescent pipsqueaks take hormone-blockers that might have far-reaching effects on their health and future fertility is indeed a little nerve-wracking. But just on the heels of Rosin's piece, researchers based at Australia's Prince Henry's Institute this month released the results of the largest ever study of transsexual genetics, which compared the length of the androgen receptor (AR) gene in 112 male-to-female transsexuals and a control group of 250 "normal" men.

    11.18.2008 at 08:02pm - Comment by SoftSatin

    While I applaud you for broaching a diminishingly taboo subject, I think it fails in it's attempt to accurately inform. There have in fact been scientifically accredited and repeatable studies that have identified actual brain incongruencies in 100% of the cadavers studied. 100%. These studies have been the foundation for the increasing changes and accommodations in the legal and medical fields, and the cause for public education. Transsexualism is not related to sexual orientation as your article loosely implies. In fact the same ratio of heterosexual to homosexual individuals in the general population, relates to the transsexual population. And similarly, most male to female transsexuals are not "feminine" in physical attributes. Just as many "male to female" transgendered people have physically masculine or physically feminine characteristics as in the general population. A discussion of primary vs secondary transsexuals would be helpful here, as the long term effects of testosterone are far more apparent in secondaries. While I have never heard of the article's claim regarding "growth regulating neurons" I doubt this is creditable. The first actual evidence of a-typical brain regions was the BSTc region of the hypothalamus in 1985, followed by conclusive studies in 1995 and 2000. I have heard of the research on finger length. As I remember, the results were not statistically significant to substantiate any of the hypothesises, or to lend credit to any wives-tales. Listing your sources for including this in your article would be helpful here. Genetic research is promising and warranted. But far too often transsexualism has born the brunt of misleading, incorrect, and even malicious reporting. I believe that because of this history, more effort should be provided to document information and tie claims and speculation to actual studies and verifiable results. In this regard, you did accurately portray the DSM-IV classification, and the effort to characterize the outdated basis for its current state. IMO I would like to see the discussion moved forward to begin the disclosure of how this condition came to be excluded from insurance coverage in the USA, but is now included in the public health care system of both large and small countries around the world. Again the US lags behind while we tell ourselves we are the leader of the world.



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