You may have begun as a spark in your parents' eyes, but in the Kyoto University lab of Katsuhiko Hayashi and Mitinori Saitou, baby mice begin life as… skin cells.
After a decade of work, the two biologists have developed a way to turn mice's skin cells into "pre-egg" and "pre-sperm" cells of sorts, Nature reports. The cells are actually called primordial germ cells, with "germ" here meaning eggs and sperm, not germs like the ones you wash off your hands after going to the bathroom.
Once implanted in the testes of infertile adult mice, the primordial germ cells turn into sperm that allow the mice to father healthy-seeming pups. When implanted into the ovaries of a female adult mouse, the primordial germ cells become eggs that researchers are able to fertilize in vitro and turn into pups.
The Nature feature provides an engaging overview of this very cool technology. It's a nice long read. We'll just note one important caveat. The Japanese scientists originally meant to help other scientists, not infertility patients. The primordial germ cells are great for certain genetic experiments, and Hayashi and Saitou figured out a way to make millions of them in the lab. Although their technique sounds provocative, they weren't thinking about infertile couples wishing to have their own biological children.
However, after receiving about a dozen letters, plus an inquiry from the editor of a magazine for gay and lesbian readers, the Japanese lab is preparing to study whether this could work in humans. It has a grant to study the technique in monkeys.
It will be a long road. Hayashi told Nature that preparing for human studies will be much like starting over from scratch, and that an infertility treatment would not be ready for decades.
This is awesome. Can't wait to see the results replicated for humans.
Science has once again confirmed that men are superior to women because sperm from women can only produce female offspring whereas man eggs could produce either male or female offspring depending on the sperm used. I tease but seriously this is gross and also cool but mostly gross. I wonder if science can transplant chromosomes. Future news will have lesbian couple searching for a y chromosome donor for their triparent son.
Has science gone too far?
No, so shut up and keep your religious beliefs to yourself. The world will thank you.
I am curious of how they know the difference of natural made sperms verse the the germ cells, then outputted sperm from the testes?
"...Once implanted in the testes of infertile adult mice, the primordial germ cells turn into sperm that allow the mice to father healthy-seeming pups. When implanted into the ovaries of a female adult mouse, the primordial germ cells become eggs that researchers are able to fertilize in vitro and turn into pups..."
And how do we know the difference of natural made egg cells vers the germ cells, which later were removed in vitro and turned into pups?
Were there little coded signs on the newly made germ\sperm to easily identify them from the natural sperm?
Were there little coded signs on the newly made germ\eggs too, verse the naturally made egg found in the ovaries?
Excellent news. The world needs more mice.