The Elderly
The Elderly Wikimedia Commons

Researchers at the German Cancer Research Center in Heidelberg have discovered a particular molecule, named Dickkopf-1 or Dkk1, that seems to have a positive effect on cognition in the elderly. Typically, as humans (and rats) age, they produce fewer neurons, which inhibits cognitive abilities. But when Dkk1 is blocked, older rats tested just as well as younger rats on memory and recognition tests.

Interestingly, blocking Dkk1 also decreases depression--it's unclear if that's due to how that molecule interacts with the brain's neuron-producing parts, but Dkk1 and depression certainly seem to be correlated. A researcher from the facility says they are working on possible clinical uses for a Dkk1-blocker.

6 Comments

"Dkk1, that seems to have a positive effect on cognition in the elderly"
Shouldn't that be "Negative effect" as the benefits come from blocking it?

Dan Nosowitz must have the "Dickkopf Molecule" surging at unusually high levels within his brain if he thinks I believe the veracity of this story.

Aptly named molecule. Means stubborn or mule. Literally means thick head.

"kopf" is German for "head". So it is the "dickhead" gene that is the problem as guys get older? Being a dickhead is genetic?

I am sure this is some sort of joke. As Michael mentions it means stubborn. Which can be negative or positive. In the elderly it might refer to set patterns which is not necessarily negative. I think the original statement was released on April 1st.



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