Nematodes Change Direction These nematodes contain nanoparticles that warm up when exposed to a magnetic field. The warmth makes the worms wriggle in a different direction. University of Buffalo

Researchers in Buffalo are bringing us a step closer to being controlled by machines. Or magnetized nanoparticles, at least: Heated magnetic nanoparticles targeted to cell membranes could control your behavior, according to a new paper in Nature Nanotechnology.

The researchers, led by University of Buffalo physics professor Arnd Pralle, used magnetic fields to activate neurons in a cell culture and steer the movement of nematode worms.

The findings could lead to cancer treatments that remotely manipulate cells in certain tissues, or diabetes therapies that remotely stimulate pancreatic cells to release insulin, according to the University of Buffalo.

The system works by exposing 6-nanometer-sized particles in a cell membrane to a magnetic field, which heats them up. The field is comparable in strength to the kind used in magnetic resonance imaging. When the temperature reaches 34 degrees Celsius (93.2 F), the cells react -- that's the temperature that provokes a natural avoidance response, the researchers say.

In this video, the nematodes (C. elegans) are wriggling around; they change direction when the magnetic field is switched on, warming the nanoparticles to 34 C.


The method does not harm the cells, Pralle says. While the membrane outside the cell heats up, there is no temperature change inside. Pralle and his team even devised a nano-thermometer to measure this effect. They used a fluorescent probe, and changes in the fluorescence intensity indicated the change in temperature.

Because the cells are not harmed, the method can be used in living animals, which opens the door for specialized pharmaceuticals or therapies. It can also illuminate the signaling networks that control animal behavior, Pralle says.

[ScienceDaily]

6 Comments

Those nanoparticles move grotesquely like tiny worms, but hey, if some smart guys and gals can make these nano worms do something useful then that's pretty cool.

Just one more invention that will eventually turn into a weapon. Cool stuff though.

From the linked article it looks like the particles are not actually causing neurons to fire- they just cause the worms to freak out when they sense heat at their front ends. Very cool?- Yes! Mind control?- Not really.

The nano-thermometer is a very neat gadget. I hope they remembered to apply for a patent!

@mcrobq - those aren't the nanoparticles. Those are worms. The nanoparticles are *in* the worms.

And yes, "scientists stimulate nerves to make change direction" = "scientist threatens you with tire iron and you respond by changing direction." But yes, still cool.

Hey, what happens when human neurons 'freak out' on a large scale? Does the human also freak out or does he go brain-dead and become a zombie?

You guys don't understand. You need to read the linked article again more carefully.

It's not "the worms feel heat and move away". It's "the heat opens ion channels, stimulating neurons and causing the worms to change direction". Opening calcium ion channels is what neurotransmitters, such as acetylcholine, do naturally to invoke an electrical nerve response. Trust me on this one--it's one of only a few things I actually knew on my recent Cell Bio final.

-IMP ;) :)



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