“Cancer treatments have hit a wall,” says chemist Michael J. Sailor of the University of California at San Diego. Today’s chemotherapy drugs leave the body too quickly, and both chemo and radiation kill healthy cells indiscriminately, he explains. So he has developed “nanoworms,” strings of iron-oxide particles that could swim through your blood to kill nascent cancerous tumors—and nothing else.
This past spring, Sailor published his preliminary results from rodent studies showing that the worms can congregate in tumors, a critical first step to delivering medication directly to cancerous cells. One key to the worms’ success is their shape. The liver or other immune cells swallow up single nanoparticles in minutes, well before they can accumulate in a tumor. But previous studies have shown that longer molecules, like the worms and viruses, can evade these defense mechanisms for up to 24 hours. This gives the worms, which can be loaded with chemotherapy drugs and coated with molecules that bind only to cancerous cells, enough time to circulate throughout the body and hunt tumors. Once the worms latch onto a tumor, they would release their payload. Meanwhile, the body would naturally excrete any unbound iron oxide.
The first use in humans, Sailor says, could be for tumor detection. It turns out that worm-covered tumors show up more vividly on MRI scans, making it possible to catch tumors at an earlier stage. Sailor plans to recruit patients and begin clinical trials by 2010. Below, a look at how drug-filled worms could wipe cancer from your body.

STEP 2: Coated with tumor-specific proteins, the worms home in on the cancer. Their elongated shape allows
the proteins to latch onto the tumor at multiple points.
STEP 3: Doctors perform an MRI on the patient. The iron-oxide worms react strongly to the magnetic scanner, producing brighter images of young tumors than traditional scanning techniques do.
STEP 4: The medication can be released using enzymes, heat or a time-release mechanism.
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Very cool, i'm glad that there is progress being made in the fight against cancer.
Why use iron oxide?
This is the one thing I don't like about Pop Sci. They don't always do enough reasearch. YES, this is BRILLIANT technology, but guess what, folks, it's already here, not years away. Celsion Corporation's "Thermodox" treatment is this, and in some ways more, because it also has an effect on shutting down tumor vasculature. You can see it all at www.celsion.com They are already in pahse 3 clinical trials and having incredible results in humans. The technology was invented at Duke, and Celsion is years ahead.
Nanotechnology and temperature sensitve liposomes are two different technologies directed similar goals. Thermodox uses low temperature sensitive liposomes to encapsulate doxorubicin, a common cancer drug. Popular Science is reporting about iron oxide nanoparticles as a method of drug delivery or MRI associated enhanced detection. Thermodox is a treatment only. This nanotechnology can not only treat tumors but also detect neoplasia at an earlier time leaving a patient with a better prognostic outcome.
From what I read on the Celsion web page they are way ahead of this technology. They are using nano size particles of a know cancer kill and encapsulating it to make a heat sensitive liposome to attack tumors. Anyone with liver cancer or reoccurring breast cancer should look into their clinical trials. Thanks Odat For the link. NANOCURE
They didn't say anything about what the treatment's cost is... anyways, if it really helps to eliminate cancer then - way to go!... but what if it's too expensive?! Can the healthcare card of a person provide him or her with enough coverage to include these kinds of treatments? Or is it just one of those "cures" that are good only for those who can actually "afford" them?
That great but......how much are we willing to pay for theese type of things?
But way to go!!!
^^
-THE KID
Any kind of Cancer treatment article interests me greatly, and this one is no different. This shows the further development of cancer cures that are designed to target strictly the tumor, for as is said in the article, modern Chemo technology kills both healthy and unhealthy cells. Where as it is true that this is not the only research in this field, the particular type of treatment laid forth in the article does look especially promising. One reason for this is these iron toting 'nanoworms' ability to help us spot tumors earlier than previously capable. This is a great article, but one thing we readers are left without is the estimated cost of these procedures, which could most certainly be a downfall to such a great innovation. Overall, this was a very informative and well written article, and I'm excited to be seeing more and more articles of this sort around lately.
This is cool stuff, 'tho the idea of worm-like things in me would freak me out a little. =) However, the benefits are worth the discomfort.
I found this article very interesting, and I was excited to learn about a new way that might be able to treat cancer. I think that any new technology about being able to cure cancer is always exciting, and this treatment seems very promising. I think that the article was well written and I was excited to see that it showed the steps in how this treatment works. I hope that it can be ready by 2010 for more trials. One big thing that the article left out was the cost of this treatment. I hope that this treatment can be a big step in curing cancer and detecting tumors.
Great! Maybe we will finally find a cure against cancer now. This could turn into a real lifesaver!
from Montreal, Quebec
I am currently working in an Radiation Oncology clinic.
I am happy that progress is made with cancer treatment research, but as far as I can understand, this works mostly for "young tumors". For non-advanced tumors, there are many treatment options available that preserve the person's normal way of life.
What I would be interested in seeing is a treatment for both locally & distally advanced cancers (metastases). So far, chemo has been the only systemic therapy, with the concurrent help of radiation locally.
As for tumor detection, I still think we are pretty good at it as it is. With the few exceptions of head and neck cancers (larynx/pharynx) which usually are undetectable at earlier stages.
The problem still resides at screening. Today we know that ANYONE is prone to get some sort of cancer: from infants to the elderly. How do we screen everyone?
- DiGGY
from Poultney, VT
I feel that, not only Iron (Atomic Wt.26) But also Cobalt(Atomic Wt.27) Could and would destroy cancer cells. The problem is, a B-12 shot is only 1000mcg or 43mcg of Cobalt.
B12 is 4.3% Cobalt. If you would give a B12 shot of 40,000mcg of B12, that is 1720mcg of Cobalt. B12 can already destroy most viruses topically. To bad the medical profession can't figure that out, or don't want to. The cure for the Flu & Cold with nasal B12 is explained at www.popsci.com/node/22953
Pokeris I posted link to you articles , realy nice
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