The most promising new treatment for severe depression isn't a pill. It's a permanent implant that shocks the brain. Is this what joy looks like?
In the middle of room #11 in the Cleveland Clinic's surgical center, Diane Hire lies on an operating table, the back half of her shaven head hidden behind a plastic curtain. Four pins, one driven into either side of her forehead, the other two in back, hold a titanium halo fast to her skull. An anesthesiologist, several nurses and her psychiatrist cluster around the bed.
Behind the curtain, neurosurgeon Ali R. Rezai surveys Hire's brain, white and snaked with thin red arteries, through a pair of small holes he's drilled in the top of her skull.